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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline

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Tarsal Tunnel Syndrome Tarsal tunnel syndrome compression of the posterior tibial nerve is frequently confused with plantar fasciitis, neuropathy, or other conditions

These predictive models should be interpreted cautiously and not equated with confirmed metabolic outputs

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